Introduction

A lifetime of healing patients, understanding how the body heals itself and endless hours of research and development into the molecular-level secrets of the human body led to the establishment of Thione International, Inc. The following is background information on how a unique Georgia biotechnology company has brought to life a visionary physician's ideas to help each of us heal ourselves.

History of Thione International and Background on Theodore Hersh, M.D.

Thione International, Inc. was founded in 1995 and is headquartered in Atlanta, Georgia. Theodore Hersh, M.D., Professor of Medicine, Emeritus, Emory University and his wife, Rebecca, launched Thione based on Dr. Hersh's 30 years of clinical practice and research experience as a gastroenterologist-hepatologist. One of his many strengths is a vast knowledge in the field of nutrition and a keen interest in preventative medicine.

Dr. Hersh graduated from Harvard with a Bachelor of Arts Degree, Cum Laude, in Biology. He attended medical school at Columbia University, College of Physicians and Surgeons, in New York City and had his postgraduate training in Internal Medicine and Gastroenterology at Mt. Sinai Hospital in New York, The Mayo Clinic in Rochester, Minnesota, and the Boston City Hospital, Harvard Division, in Boston, Massachusetts.

During Thione's first four years, the founders focused on designing formulations, developing applications, conducting patent and clinical research and submitting patent applications. Those efforts led to the formation of a technology platform that incorporates sixteen products supported by considerable scientific research and several clinical studies performed by independent research laboratories as well as unaffiliated researchers that support the products. Following the successful outcome of the research and related studies, Thione began to commercialize its unique, patented Thione Complex™ that is the basis for a growing family of products. The company's focus was to develop a base of business built on the commercial efficacy of its technology.

Thione's annual revenue stream supports a proven commercial as well as clinical efficacy. The company expanded its branding strategy from a retail perspective to licensing and distribution. Concentrating on its strengths in application development and scientific research and development, its licensing and distribution strategy has keyed on forming alliances with quality partners that provide manufacturing, marketing and distribution expertise.

Thione's efforts are concentrated on providing the Thione Complex™ on a global basis through partnering with companies whose strengths complement its molecular-level delivery system.

Company Profile

Thione International, Inc. is a healthcare technology company founded to develop applications utilizing a powerful synergistic combination of antioxidants consisting of L-glutathione, selenium and other antioxidants, enzymes and minerals that replicate the body's cellular antioxidant defense network. The company's patented compounds and novel delivery methods:

• Prevent damage to cell structure and function
• Protect lipoproteins
• Reduce damage to DNA

L-Glutathione is the body's chief protector and has multiple functions in disease prevention and in detoxification of chemicals and drugs. In addition to these capabilities, glutathione acts as a donor molecule that regenerates oxidized antioxidant compositions such as vitamins C and E back to their original molecular configuration.

Developed by Dr. Hersh, this biochemical rejuvenation process forms the basis of the Thione Complex™ that creates unique and powerful preventative and therapeutic healthcare applications. Under his guidance, the company has developed unique applications and products for various healthcare markets. Concentrating on its research and development competencies, Thione is developing both manufacturing and marketing relationships with strategically selected partners. The company has formed developmental relationships with several companies. In addition to the core strengths of its technology, there are other factors that position Thione for worldwide growth, including:

Business Model
Management has formulated a vertically integrated strategy in which it focuses on its core competencies, research and product development. Thione seeks to demonstrate how its applications can provide manufacturers with product differentiation by improving product performance or brand extension.

Results and Collaborations
In addition to its recurring base of business, Thione has formed relationships with several large tobacco companies and has introduced its oral care applications to national and international consumer product organizations, pharmaceutical companies, niche manufacturers and major distributors.

Platform of Intellectual Property

Thione's intellectual property includes:

• Numerous laboratory and clinical test results
• Trade secrets in the form of manufacturing methods and product formulations
• Eighteen patent applications protecting its compositions and methods of delivery to the body

Thus far:

• Fifteen of Thione's patent submissions have been granted by the United States Patent and Trademark Office
• Five have been filed internationally
• The remaining submissions are pending

Development of Advanced Applications

The Company has 16 commercially available product applications in niche market areas such as:

• Oral care
• Nutriceuticals/Immune System Boosters
• Dermatologics
• Aesthetics/Cosmetics
• Pain management

Summary

The enhancement of existing consumer products, allows Thione International, Inc. to be highly sought after by many market and industry segments. The Company's technology and products are highly beneficial and of global importance.